長期從事酵母合成生物學相關的應用基礎研究，包括釀酒酵母基因組減小底盤細胞構建和芳香化合物微生物細胞工廠的設計與優化。已發表SCI學術論文20余篇，其中以第一作者在 Nature Communications，Current Opinion in Biotechnology及Research in Microbiology等期刊發表論文多篇。受邀擔任Frontiers in Bioengineering and Biotechnology評審編輯及ACS Synthetic Biology，Microbial Cell Factories， International Journal of Food Microbiology等學術期刊審稿人。
2005.09-2009.07 天津師范大學，生物科學 ，理學學士
2009.09-2015.06 南開大學， 微生物學（碩博），理學博士（導師：喬明強教授）
2015.09-2020.06 查爾姆斯理工大學，合成生物學，博士后（導師：Jens Nielsen院士）
2022.05-至今 中國科學院青島生物能源與過程研究所，研究員
已發表論文：
1. Liu Q, Yu T, Campbell K, Nielsen J, Chen Y*. Rewiring carbon metabolism in yeast for high level production of aromatic chemicals. Nature Communications. 2019, 10(1):4976.
2. Liu Q#, Liu Y#, Li G, Savolainen O, Chen Y, Nielsen J*. De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories. Nature Communications. 2021, 12(1):6085.
3. Liu Q, Liu Y, Chen Y, Nielsen J*. Current state of aromatics production using yeast: achievements and challenges. Current Opinion in Biotechnology. 2020, 65:65-74.
4. Liu Q, Wu Y, Chen Y, Bai Y, Xu H*, Qiao M*. mazF-mediated deletion system for large genome rearrangements in Saccharomyces cerevisiae. Research in Microbiology. 2014, 165(10):836-840.
5. Liu Q, Gao G, Xu H, Qiao M*. Identification of the bacteriocin subtilosin A and loss of purL results in its high-level production in Bacillus amyloliquefaciens. Research in Microbiology. 2012, 163(6-7):470-8.
6. Liu Q, Yu T, Campbell K, Nielsen J*, Chen Y. Modular pathway rewiring of yeast for amino acid production. Methods in Enzymology. 2018, 608:417-439.
7. Liu Q, Liu H, Yang Y, Zhang X, Bai Y, Qiao M, Xu H*. Scarless gene deletion using mazF as a new counter-selection marker and improved deletion cassette assembly method in Saccharomyces cerevisiae. The Journal of General and Applied Microbiology. 2014, 60(2):89-93.
8. Li X, Wang Y, Li G, Liu Q, Pereira R, Chen Y, Nielsen J*. Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis. Nature Catalysis. 2021, 4(9):783-796.
9. Yu T#, Zhou YJ#, Huang M, Liu Q, Pereira R, David F, Nielsen J*. Reprogramming yeast metabolism from alcoholic fermentation to lipogenesis. Cell. 2018, 174(6):1549-1558.
10. Liu Y, Liu Q, Krivoruchko A, Khoomrung S, Nielsen J*. Engineering yeast phospholipid platform for de novo oleoylethanolamide production. Nature Chemical Biology. 2020, 16(2):197-205.
11. Yu T, Zhou YJ, Wenning L, Liu Q, Krivoruchko A, Siewers V, Nielsen J, David F*. Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals. Nature Communications. 2017, 8:15587.
12. Wang G, Bj?rk S, Huang M, Liu Q, Campbell K, Nielsen J, J?nsson H*, Petranovic D*. RNAi gene expression tuning, microfluidic screening, and genome recombineering for improved protein production in yeast. Proceedings of the National Academy of Sciences. 2019, 116(19):9324-9332.
13. Li Y, Mao J, Liu Q, Song X, Wu Y, Cai M, Xu H, Qiao M*. De novo biosynthesis of caffeic acid from glucose by engineered Saccharomyces cerevisiae. ACS Synthetic Biology. 2020, 9(4):756-765.
14. Song X, Li Y, Wu Y, Cai M, Liu Q, Gao K, Zhang X, Bai Y, Xu H, Qiao M*. Metabolic engineering strategies for improvement of ethanol production in cellulolytic Saccharomyces cerevisiae. FEMS Yeast Research. 2018, 18(8).
15. Song X, Liu Q, Mao J, Wu Y, Li Y, Gao K, Zhang X, Bai Y, Xu H, Qiao M*. POT1-mediated δ-integration strategy for high-copy, stable expression of heterologous proteins in Saccharomyces cerevisiae. FEMS Yeast Research. 2017, 17(6).
16. Wu Y, Liu Q, Chen Y, Xu H, Pastinen O, Turunen Q, Qiao M*. Large genome deletions reveal gene effects on ethanol tolerance in Saccharomyces cerevisiae. Journal of Food Science & Technology. 2019, 4(6):815-821.
17. Wu Y, Cai M, Song X, Li Y, Wang H, Mao J, Liu Q, Xu H, Qiao M*. Comparative transcriptome analysis of genomic region deletion strain with enhanced L-tyrosine production in Saccharomyces cerevisiae. Biotechnology Letters. 2020, 42(3):453-460.
18. Mao J, Liu Q, Song X, Wang H, Feng H, Xu H, Qiao M*. Combinatorial analysis of enzymatic bottlenecks of L-tyrosine pathway by p-coumaric acid production in Saccharomyces cerevisiae. Biotechnology Letters. 2017, 39(7):977-982.
19. Li Y, Mao J, Song X, Wu Y, Cai M, Wang H, Liu Q, Zhang X, Bai Y, Xu H, Qiao M*. Optimization of the l-tyrosine metabolic pathway in Saccharomyces cerevisiae by analyzing p-coumaric acid production. 3 Biotech. 2020, 10(6):258.
20. Mao J, Liu Q, Li Y, Yang J, Song X, Liu X, Xu H, Qiao M*. A high-throughput method for screening of L-tyrosine high-yield strains by Saccharomyces cerevisiae. The Journal of General and Applied Microbiology. 2018, 64(4):198-201.
21. Gao W, Dai S, Liu Q, Xu H, Qiao M*. CitB mutation increases the alkaline protease productivity in Bacillus subtilis. The Journal of General and Applied Microbiology. 2010, 56(5):403-407
22. Gao W, Dai S, Liu Q, Xu H, Bai Y, Qiao M*. Effect of site-directed mutagenesis of citB on the expression and activity of Bacillus subtilis aconitase. Microbiology. 2010, 79(6):774-778
其他已發表論文與著作
1. Yu T, Dabirian Y, Liu Q, Siewers V, Nielsen J*. Challenges and strategies for metabolic rewiring. Current Opinion in Systems Biology. 2019, 15:30-38.
2. Pereira R, Ishchuk O, Li X, Liu Q, Liu Y, Otto M, Chen Y, Siewers V, Nielsen J*. Metabolic Engineering of Yeast. In Metabolic Engineering: Concepts and Applications (Volume 13a, eds Nielsen J, Stephanopoulos G, Lee S) 689-733 (WILEY-VCH GmbH, Weinheim, 2021).
聯系方式：
liuql@qibebt.ac.cn
