絲狀真菌是一類非常重要的工業微生物，在醫藥、食品、化工和農業領域都具有廣泛的應用。微生物制造工程中心聚焦重要醫藥產品生產工藝復雜低效的共性問題，通過發展合成生物技術推動多個重要產品生產工藝的綠色升級，低產到優產、多步變少步、生物催化替代化學合成、微生物發酵取代傳統植物提取，提高工業過程的經濟效益與環保效益。打通了降血脂藥物辛伐他汀的全生物合成技術路線，建立了殺線劑 F606 的微生物發酵生產線，實現了中藥大黃活性成分大黃素甲醚的微生物高效合成。多項成果與海正藥業、魯抗醫藥等國內知名企業實現技術轉讓，推動傳統生產工藝的綠色升級和新型生物農藥創制。

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1. Xuenian Huang, Ping Men, Shen Tang, Xuefeng Lu*, 2021，Aspergillus terreus as an industrial filamentous fungus for pharmaceutical biotechnology. Current Opinion in Biotechnology，69，273-280.

2. Xuenian Huang, Shen Tang, Linghui Zheng, Yun Teng, Yong Yang, Jinwei Zhu, Xuefeng Lu*, 2019, Construction of an efficient and robust Aspergillus terreus cell factory for monacolin J production, ACS Synthetic Biology, 8(4):818-825

3. Bo Liang, Xuenian Huang, Yun Teng, Yajing Liang, Yong Yang, Linghui Zheng, Xuefeng Lu*, 2018, Enhanced single-step bioproduction of the simvastatin precursor monacolin J in an industrial strain of Aspergillus terreus by employing the evolved lovastatin hydrolase, Biotechnology Journal, 10:e1800094

4. Xuenian Huang, Yajing Liang, Yong Yang, Xuefeng Lu*, 2017, Single-step production of the  simvastatin precursor monacolin J by engineering of an industrial strain of Aspergillus terreus, Metabolic Engineering, 42:109-114

5. Xuenian Huang, Mei Chen, Jianjun Li, Xuefeng Lu*, 2016, Establishing an efficient gene-targeting system in an itaconic-acid producing Aspergillus terreus strain, Biotechnology Letters, 38(9):1603-1610

6. Mei Chen, Xuenian Huang, Chengwei Zhong, Jianjun Li, Xuefeng Lu*, 2016, Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus, Applied Microbiology and Biotechnology, 100(17):7541-7548

7. Xuenian Huang, Mei Chen, Xuefeng Lu, Yueming Li, Jian-Jun Li*, 2014, Direct production of itaconic acid from liquefied corn starch by genetically engineered Aspergillus terreus, Microbial Cell Factories, 13(0):108

8. Xuenian Huang, Xuefeng Lu, Yueming Li, Xia Li, Jian-Jun Li*, 2014, Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain, Microbial Cell Factories, 13(0):119

9. Xuenian Huang, Xuefeng Lu, Jianjun Li*, 2014, Cloning, characterization and application of a glyceraldehyde-3-phosphate dehydrogenase promoter from Aspergillus terreus, Journal of Industrial Microbiology and Biotechnology, 41(3):585-592